同义词

H2A Barr body-deficient; H2A.Bbd; H2ABBD; H2AFB

UniProt ID

P0C5Z0

UniProt名字

H2AB2_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

H2AFB2

生物

Human

氨基酸序列

>lcl|BSEQ0013500|Histone H2A-Bbd type 2/3 MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVI EYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED

目标基因序列

残基数

115

分子量

12713.25

理论 pI

一般功能

Dna binding

具体功能

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013501|Histone H2A-Bbd type 2/3 (H2AFB2) ATGCCGAGGAGGAGGAGACGCCGAGGGTCCTCCGGTGCTGGCGGCCGGGGGCGGACCTGC TCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTGGAGCGCAGTCTACGG GAGGGCCACTACGCTCAGCGCCTGAGTCGCACGGCGCCGGTCTACCTCGCTGCGGTTATT GAGTACCTGACGGCCAAGGTCCTGGAGCTGGCGGGCAACGAGGCCCAGAACAGCGGAGAG CGGAACATCACTCCCCTGCTGCTGGACATGGTGGTTCACAACGACAGGCTACTGAGCACC CTTTTCAACACGACCACCATCTCTCAAGTGGCCCCTGGCGAGGACTAG

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:18298

染色体位置

轨迹

信号区域

Pdb标识

KEGG ID

hsa:474381

细胞的位置

Nucleus