同义词

H2A Barr body-deficient; H2A.B; H2A.Bbd

UniProt ID

P0C5Y9

UniProt名字

H2AB1_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

H2AFB1

生物

Human

氨基酸序列

>lcl|BSEQ0017634|Histone H2A-Bbd type 1 MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVI EYLTAKVPELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED

目标基因序列

残基数

115

分子量

12697.21

理论 pI

一般功能

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).

具体功能

Dna binding

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0017635|Histone H2A-Bbd type 1 (H2AFB1) ATGCCGAGGAGGAGGAGACGCCGAGGGTCCTCCGGTGCTGGCGGCCGGGGGCGGACCTGC TCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTGGAGCGCAGTCTACGG GAGGGCCACTACGCTCAGCGCCTGAGTCGCACGGCGCCGGTCTACCTCGCTGCGGTTATT GAGTACCTGACGGCCAAGGTCCCGGAGCTGGCGGGCAACGAGGCCCAGAACAGCGGAGAG CGGAACATCACTCCCCTGCTGCTGGACATGGTGGTTCACAACGACAGGCTACTGAGCACC CTTTTCAACACGACCACCATCTCTCAAGTGGCCCCTGGCGAGGACTAG

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:22516

染色体位置

轨迹

Xq28

信号区域

Pdb标识

KEGG ID

hsa:474382

细胞的位置

Nucleus