同义词

H2A/z; H2AZ

UniProt ID

P0C0S5

UniProt名字

H2AZ_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

H2AFZ

生物

Human

氨基酸序列

>lcl|BSEQ0019689|Histone H2A.Z MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILE YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG KKGQQKTV

目标基因序列

残基数

128

分子量

13552.635

理论 pI

一般功能

Rna polymerase ii distal enhancer sequence-specific dna binding

具体功能

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0019690|Histone H2A.Z (H2AFZ) ATGGCTGGCGGTAAGGCTGGAAAGGACTCCGGAAAGGCCAAGACAAAGGCGGTTTCCCGC TCGCAGAGAGCCGGCTTGCAGTTCCCAGTGGGCCGTATTCATCGACACCTAAAATCTAGG ACGACCAGTCATGGACGTGTGGGCGCGACTGCCGCTGTGTACAGCGCAGCCATCCTGGAG TACCTCACCGCAGAGGTACTTGAACTGGCAGGAAATGCATCAAAAGACTTAAAGGTAAAG CGTATTACCCCTCGTCACTTGCAACTTGCTATTCGTGGAGATGAAGAATTGGATTCTCTC ATCAAGGCTACAATTGCTGGTGGTGGTGTCATTCCACACATCCACAAATCTCTGATTGGG AAGAAAGGACAACAGAAGACTGTCTAA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:4741

染色体位置

4

轨迹

信号区域

Pdb标识

1F66; 3WA9; 4CAY; 4NFT

KEGG ID

hsa:3015

细胞的位置

Nucleus