同义词

ALTPRP; ASCR; PRIP; PRP; PrP27-30; PrP33-35C

UniProt ID

P04156

UniProt名字

PRIO_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

PRNP

生物

Human

氨基酸序列

>lcl|BSEQ0002199|Major prion protein MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV ILLISFLIFLIVG

目标基因序列

残基数

253

分子量

27661.21

理论 pI

9.23

一般功能

Tubulin binding

具体功能

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (PubMed:12732622, PubMed:19936054, PubMed:20564047). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

跨膜区

GenBank 蛋白质 ID

190468

目标蛋白质序列

基因序列

>lcl|BSEQ0019060|Major prion protein (PRNP) ATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGC CTCTGCAAGAAGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGG CAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCT CATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTGGC TGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAAC AAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCA GTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACAT TTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAA GTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTC AATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAGAACTTCACCGAG ACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAGG GAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACCTGTG ATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGA

GenBank 基因 ID

M13899

基因卡 ID

Genatlas ID

PRNP

HGNC ID

HGNC:9449

染色体位置

20

轨迹

20p13

信号区域

2022/1/22 0:00:00

Pdb标识

1E1G; 1E1J; 1E1P; 1E1S; 1E1U; 1E1W; 1FKC; 1FO7; 1H0L; 1HJM; 1HJN; 1I4M; 1OEH; 1OEI; 1QLX; 1QLZ; 1QM0; 1QM1; 1QM2; 1QM3; 2IV4; 2IV5; 2IV6; 2K1D; 2KUN; 2LBG; 2LEJ; 2LFT; 2LSB; 2LV1; 2M8T; 2OL9; 2W9E; 3HAF; 3HAK; 3HEQ; 3HER; 3HES; 3HJ5; 3HJX; 3MD4; 3MD5; 3NHC; 3NHD; 3NVF; 4DGI; 4E1H; 4E1I; 4KML; 4N9O

KEGG ID

hsa:5621

细胞的位置

Cell membrane