Lysine-specific demethylase 4A
同义词
1.14.11.-; JHDM3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; Jumonji domain-containing protein 2A; KIAA0677
氨基酸序列
>lcl|BSEQ0008939|Lysine-specific demethylase 4A
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYD
DIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERK
YWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRH
KMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYG
KQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDL
SSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEE
QAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPL
SKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNET
MAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSL
RGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRT
AGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEG
EVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSV
ASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
具体功能
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
基因序列
>lcl|BSEQ0017640|Lysine-specific demethylase 4A (KDM4A)
ATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGACCTTTTATCCAACT
ATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCAT
CGGGCAGGGCTAGCCAAGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGAT
GACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGACGGGGCAGTCTGGC
CTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATA
GCCAATAGCGATAAGTACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAA
TACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATGTGAATGGTACCCTC
TATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTG
GAAAAGGAGAGTGGGATCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATG
TGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACAGCATCAACTACCTG
CACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAA
CGCCTCGCCAAAGGCTTTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCAC
AAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTCCCTTTGACAAGGTG
ACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAAC
CATGGTTTTAACTGTGCGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGC
AAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCTCCATGGATGTGTTT
GTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTT
ATTGACCATACTCTGCCCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCT
CCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAGGGGTGGAGGATGGA
GAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGA
GTTTGTCTTGAAATACCACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTG
AGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCCCTGTGAGGCCCACC
CATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACT
GAAGTCAAATTTGAAGAGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAA
CAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAGGGGGACGCCTTGTC
TTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCT
ATCTCTTCTGATTCAGAAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGA
GTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTGTGGGAGAGCCATGC
ACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCA
GATGAATACATGTTTTCCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTA
AGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCAGTGATGATGAGACA
TCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTG
AGCCAACTGTGGCAGAACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACC
ATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGACTTATCATCAGGTT
GAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAG
AGGACCAAGCCATTGATTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATC
AACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCGTTTCCTGCAAGAAG
TGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGAC
TGGATGTGTTCTCGGTGTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTA
CGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACGTTTCATGTGCTGTG
GCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAA
ATCCCCCTGCCCCGCTTCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACT
GCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCTTCCATGTGAGCTGC
GCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACC
TGCTTTCGGCACAAGATTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACT
GCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACCAGTGTGAAGTGGTC
AGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAAT
CTTTATCCTGAGGACATAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGG
GAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCAAGTTTGTGGCCTCC
CACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGA
GATGATGTATACACACTGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGTCAGTA
GCCTCAGACATGCGCTTCAATGAGATTTTCACAGAGAAAGAGGTTAAGCAAGAAAAGAAA
CGGCAACGAGTTATCAACTCAAGATACCGGGAAGATTATATTGAGCCTGCACTATACCGG
GCCATCATGGAGTAG
Pdb标识
2GF7; 2GFA; 2GP3; 2GP5; 2OQ6; 2OQ7; 2OS2; 2OT7; 2OX0; 2P5B; 2PXJ; 2Q8C; 2Q8D; 2Q8E; 2QQR; 2QQS; 2VD7; 2WWJ; 2YBK; 2YBP; 2YBS; 3NJY; 3PDQ; 3RVH; 3U4S; 4AI9; 4BIS; 4GD4; 4URA; 4V2V; 4V2W