同义词

Inward rectifier K(+) channel Kir7.1; Potassium channel, inwardly rectifying subfamily J member 13

UniProt ID

O60928

UniProt名字

KCJ13_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

KCNJ13

生物

Human

氨基酸序列

>lcl|BSEQ0008952|Inward rectifier potassium channel 13 MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

目标基因序列

残基数

360

分子量

40529.195

理论 pI

一般功能

Inward rectifier potassium channel activity

具体功能

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

跨膜区

54-78 134-155

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0017645|Inward rectifier potassium channel 13 (KCNJ13) ATGGACAGCAGTAATTGCAAAGTTATTGCTCCTCTCCTAAGTCAAAGATACCGGAGGATG GTCACCAAGGATGGCCACAGCACACTTCAAATGGATGGCGCTCAAAGAGGTCTTGCATAT CTTCGAGATGCTTGGGGAATCCTAATGGACATGCGCTGGCGTTGGATGATGTTGGTCTTT TCTGCTTCTTTTGTTGTCCACTGGCTTGTCTTTGCAGTGCTCTGGTGCTTTTGTGGCGAA GATTGCCCGGCCAAAAAATCGAGCTTTTTCAATTCGCTTTACTGA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:6259

染色体位置

2

轨迹

信号区域

Pdb标识

KEGG ID

hsa:3769

细胞的位置

Membrane