毒素T3DB ID

T3D0224

目标BioDB ID

BE0000098

目标名称

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

目标UniProt ID

P11177

作用机理

Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (T1)

参考文献

T1 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

创建于

2009-06-19 20:15:38 UTC

更新于

2014-09-04 16:13:18 UTC

目标详情