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Fumagillin
目标名称
Methionine aminopeptidase 2
作用机理
Fumagillin blocks blood vessel formation (angiogenesis) by inhibiting the enzyme methionine aminopeptidase 2. This prevents angiogenesis by arresting endothelial cells in the G1 phase of the cell cycle. Inhibition of angiogenesis can suppress tumor growth and metastasis. Methionine aminopeptidase 2 inhibition also blocks Wnt signaling, which plays a critical role in development, cell differentiation, and tumorigenesis. (A3059, A3060)
参考文献
A3059 - Hou L, Mori D, Takase Y, Meihua P, Kai K, Tokunaga O: Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. doi: 10.1111/j.1440-1827.2009.02393.x. (19563408)
A3060 - Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM: A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 2006 Sep;13(9):1001-9. (16984890)
创建于
2010-05-19 16:44:07 UTC
更新于
2014-09-04 16:24:30 UTC