毒素T3DB ID

T3D0198

目标BioDB ID

BE0000732

目标名称

Sodium/potassium-transporting ATPase subunit alpha-1

目标UniProt ID

P05023

作用机理

The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. (L837, A250)

参考文献

A250 - Foller M, Sopjani M, Mahmud H, Lang F: Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res. 2008;31(2):87-93. doi: 10.1159/000119704. Epub 2008 Mar 5. (18319605) L837 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for vanadium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp58.html)

创建于

2009-06-18 20:16:54 UTC

更新于

2014-09-04 16:05:26 UTC

目标详情