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2,3,7,8-Tetrachlorodibenzo-p-dioxin
作用机理
CDDs are believed to disrupt the production, transport, and disposition of thyroid hormones. One mechanism of this involves metabolites of CDDs competing with thyroxine to bind to transthyretin, decreasing serum thyroid hormone levels. This change in thyroid hormone levels has been linked to both thyroid toxicity and neurobehavioral alterations. (L628)
参考文献
L628 - ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for polybrominated biphenyls and polybrominated diphenyl ethers (PBBs and PBDEs). U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp68.html)
创建于
2009-06-30 17:12:31 UTC
更新于
2014-09-04 16:14:24 UTC