Nitrite,毒素靶向作用机制

Nitrite

毒素T3DB ID

T3D0212

目标BioDB ID

BE0004556

目标名称

Hemoglobin subunit gamma-1

目标UniProt ID

P69891

作用机理

Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

参考文献

A2450 - Keszler A, Piknova B, Schechter AN, Hogg N: The reaction between nitrite and oxyhemoglobin: a mechanistic study. J Biol Chem. 2008 Apr 11;283(15):9615-22. doi: 10.1074/jbc.M705630200. Epub 2008 Jan 17. (18203719) L1613 - Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. (http://en.wikipedia.org/wiki/Methemoglobinemia)

创建于

2009-08-04 21:28:29 UTC

更新于

2014-09-04 16:05:51 UTC

目标详情