Nitrite,毒素靶向作用机制

Nitrite

毒素T3DB ID

T3D0212

目标BioDB ID

BE0000629

目标名称

Hemoglobin subunit beta

目标UniProt ID

P68871

作用机理

Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

参考文献

A2450 - Keszler A, Piknova B, Schechter AN, Hogg N: The reaction between nitrite and oxyhemoglobin: a mechanistic study. J Biol Chem. 2008 Apr 11;283(15):9615-22. doi: 10.1074/jbc.M705630200. Epub 2008 Jan 17. (18203719) L1613 - Wikipedia. Methemoglobinemia. Last Updated 22 July 2009. (http://en.wikipedia.org/wiki/Methemoglobinemia)

创建于

2009-08-04 21:27:43 UTC

更新于

2014-09-04 15:56:25 UTC

目标详情