毒素T3DB ID

T3D0135

目标BioDB ID

BE0000426

目标名称

Acetylcholinesterase

目标UniProt ID

P22303

作用机理

Guthion and its reactive metabolite, gutoxon, directly effect the nervous system by inhibiting acetylcholinesterase (AChE) in the central and peripheral nervous system. Gutoxon reacts with a serine hydroxyl group at the active site of AChE, rendering it largely unreactive. Thus acetylcholine accumulates in the neuromuscular juntions of cholinergic nerves, causing continual stimulation of electrical activity by both muscarinic and nicotinic receptors. Gutoxon has been shown to be the more potent inhibitor. (L580)

参考文献

L580 - ATSDR - Agency for Toxic Substances and Disease Registry (1990). Toxicological profile for guthion. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp188.html)

创建于

2009-06-08 20:36:13 UTC

更新于

2014-09-04 16:14:03 UTC

目标详情