毒素T3DB ID

T3D0207

目标BioDB ID

BE0003721

目标名称

Aryl hydrocarbon receptor

目标UniProt ID

P35869

作用机理

Dibenzofurans bind the aryl hydrocarbon receptor, which increases its ability to activate transcription in the XRE promoter region. This alters the expression of a number of genes. (A586)

参考文献

A586 - Ni J, Pang ST, Yeh S: Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate. 2007 Apr 1;67(5):463-71. (17252538) A9655 - Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S: Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol Cell Endocrinol. 1992 Sep;87(1-3):19-28. (1332906) A9674 - Roberts EA, Johnson KC, Dippold WG: Ah receptor mediating induction of cytochrome P450IA1 in a novel continuous human liver cell line (Mz-Hep-1). Detection by binding with [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin and relationship to the activity of aryl hydrocarbon hydroxylase. Biochem Pharmacol. 1991 Jul 15;42(3):521-8. (1650214) T148 - Long G, McKinney J, Pedersen L. Polychlorinated Dibenzofuran (PCDF) Binding to the Ah Receptor(s) and Associated Enzyme Induction. Theoretical Model Based on Molecular Parameters. Quantitative Structure-Activity Relationships. 2002;6(1):1-7.

创建于

2009-06-02 20:45:06 UTC

更新于

2014-09-04 16:10:38 UTC

目标详情