作用机理
Copper binds the N-terminal region of amyloid precursor protein, promoting the generation of 尾-amyloid from the protein. This is believed to contribute to the development of the neurodegenerative disorders Parkinson's disease and Alzheimer's disease. (A173)
参考文献
A173 - Davies P, Fontaine SN, Moualla D, Wang X, Wright JA, Brown DR: Amyloidogenic metal-binding proteins: new investigative pathways. Biochem Soc Trans. 2008 Dec;36(Pt 6):1299-303. doi: 10.1042/BST0361299. (19021544)
A9845 - Adlard PA, Bush AI: Metals and Alzheimer's disease. J Alzheimers Dis. 2006 Nov;10(2-3):145-63. (17119284)
A9846 - Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW: Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol. 2007 Mar 16;367(1):148-61. Epub 2006 Dec 21. (17239395)