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Manganese
目标名称
Iron-responsive element-binding protein 2
作用机理
Manganese alters cellular iron homeostasis by stabilizing iron regulatory protein 2. This may occur by manganese competing directly for an iron-binding site on the iron binding protein, disrupting the cellular mechanisms responsible for its iron-dependent degradation. (A159)
参考文献
A159 - Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. (17469137)
创建于
2009-05-27 20:39:31 UTC
更新于
2014-09-04 16:18:42 UTC