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Manganese
目标名称
Aconitate hydratase, mitochondrial
作用机理
Manganese interferes with amino acid metabolism by inhibiting aconitase, resulting in an increase in citrate levels. It is also believed that this direct disruption of the catalytic [4Fe-4S] cluster of aconitase by manganese produces iron regulary protein 1, resulting in alterations in cellular iron homeostasis. (A159)
参考文献
A159 - Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. (17469137)
创建于
2009-05-27 20:25:07 UTC
更新于
2014-09-04 16:18:40 UTC