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Manganese
目标名称
Putative testis-specific prion protein
作用机理
Manganese binds to the prion protein, altering its conformation, displacing copper, and altering the redox chemistry of the metal-protein complex. These changes are similar to those associated with prion disease. (A158)
参考文献
A158 - Brazier MW, Davies P, Player E, Marken F, Viles JH, Brown DR: Manganese binding to the prion protein. J Biol Chem. 2008 May 9;283(19):12831-9. doi: 10.1074/jbc.M709820200. Epub 2008 Mar 10. (18332141)
创建于
2009-05-27 20:13:55 UTC
更新于
2014-09-04 16:18:39 UTC