毒素T3DB ID

T3D0093

目标BioDB ID

BE0003721

目标名称

Aryl hydrocarbon receptor

目标UniProt ID

P35869

作用机理

Hexachlorobenzene is a weak agonist for aryl hydrocarbon receptor and may exhibit some of its toxic effects by activating the gene-regulatory properties of this protein, possibly inducing cytochome P-450 enzymes. (A157)

参考文献

A157 - Hahn ME, Goldstein JA, Linko P, Gasiewicz TA: Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist. Arch Biochem Biophys. 1989 Apr;270(1):344-55. (2539049) A9682 - Noguerol TN, Boronat S, Casado M, Raldua D, Barcelo D, Pina B: Evaluating the interactions of vertebrate receptors with persistent pollutants and antifouling pesticides using recombinant yeast assays. Anal Bioanal Chem. 2006 Jul;385(6):1012-9. Epub 2006 May 17. (16705413)

创建于

2009-05-27 16:21:40 UTC

更新于

2014-09-04 16:10:38 UTC

目标详情