当前位置：药药网 / 数据中心 / 毒素靶向作用机制
Benzidine
作用机理
N-acetylated benzidine metabolites are believed to form adducts with nucleic acids. Carcinogenesis is initiated when they are activated by peroxidation by prostaglandin H synthetase, oxidation by cytochrome P-450, or O-esterification by O-acetyltransferase or N,O-acetyltransferase. (L95)
参考文献
L95 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Toxicological profile for benzidine. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp62.html)
创建于
2009-05-26 20:12:16 UTC
更新于
2014-09-29 19:30:33 UTC