毒素T3DB ID

T3D0109

目标BioDB ID

BE0004905

目标名称

ATP-sensitive potassium channel

目标UniProt ID

P48048; P78508; Q14654; Q14500; Q9UNX9; Q99712; Q15842

作用机理

Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (A150)

参考文献

A150 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. (11454958)

创建于

2009-05-26 18:11:59 UTC

更新于

2014-09-04 16:18:00 UTC