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Barium
目标名称
ATP-sensitive potassium channel
目标UniProt ID
P48048; P78508; Q14654; Q14500; Q9UNX9; Q99712; Q15842
作用机理
Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (A150)
参考文献
A150 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. (11454958)
创建于
2009-05-26 18:11:51 UTC
更新于
2014-09-04 16:18:03 UTC