当前位置：药药网 / 数据中心 / 毒素靶向作用机制
P,P'-DDD
目标名称
Sodium channel protein type 7 subunit alpha
作用机理
DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
参考文献
A99 - Davies TG, Field LM, Usherwood PN, Williamson MS: DDT, pyrethrins, pyrethroids and insect sodium channels. IUBMB Life. 2007 Mar;59(3):151-62. (17487686)
创建于
2009-05-14 15:35:06 UTC
更新于
2014-09-04 16:15:36 UTC