毒素T3DB ID

T3D0038

目标BioDB ID

BE0000426

目标名称

Acetylcholinesterase

目标UniProt ID

P22303

作用机理

The toxic metabolites of disulfoton, mainly disulfoton sulfoxide, disulfoton sulfone, demeton S-sulfoxide and demeton S-sulfone, inhibit acetylcholinesterase in nervous tissue. The inhibition of acetylcholinesterase results in the accumulation of acetylcholine at the muscarinic and nicotinic cholinergic receptors of nerve synapses, which causes an overstimulation of cholinergic nerves and effector organs. (L123)

参考文献

L123 - ATSDR - Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for disulfoton. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp65.html)

创建于

2009-05-08 15:34:28 UTC

更新于

2014-09-04 16:14:03 UTC

目标详情