毒素T3DB ID

T3D0020

目标BioDB ID

BE0003550

目标名称

Cytochrome P450 3A43

目标UniProt ID

Q9HB55

作用机理

Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. (L91, A68)

参考文献

A68 - Nims RW, Lubet RA: Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants. J Toxicol Environ Health. 1995 Nov;46(3):271-92. (7473857) L91 - ATSDR - Agency for Toxic Substances and Disease Registry (1994). Toxicological profile for chlordane. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp31.html)

创建于

2009-05-06 16:17:42 UTC

更新于

2014-09-04 16:13:40 UTC

目标详情