当前位置：药药网 / 数据中心 / 毒素靶向作用机制
4,4'-Methylenebis(2-chloroaniline)
目标名称
Hemoglobin subunit theta-1
作用机理
MBOCA's carcinogenicity is thought to be a result of its ability to bind to DNA, hemoglobin, and serum albumin. N-oxidized MBOCA metabolites, such as n-hydroxy MBOCA and mononitroso-MBOCA, have been shown to form hemoglobin adducts. (L891)
参考文献
L891 - ATSDR - Agency for Toxic Substances and Disease Registry (1994). Toxicological profile for 4,4'-methylenebis(2-chloroaine) (MBOCA). U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp45.html)
创建于
2009-06-22 23:26:08 UTC
更新于
2014-09-04 16:10:15 UTC