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Hexachlorobenzene
目标名称
Uroporphyrinogen decarboxylase
作用机理
Hexachlorobenzene causes porphyria by modifying sulfhydryl groups in the catalytic or substrate-binding sites of uroporphyrinogen decarboxylase. This inhibits uroporphyrinogen decarboxylase, resulting in a deficiency of the decarboxylation of uroporphyrinogen III and accumulation of uroporphyrins in the liver. (A156)
参考文献
A156 - Chaufan G, Rios de Molina MC, San Martin de Viale LC: How does hexachlorobenzene treatment affect liver uroporphyrinogen decarboxylase? Int J Biochem Cell Biol. 2001 Jun;33(6):621-30. (11378443)
创建于
2009-04-14 21:08:39 UTC
更新于
2014-09-04 16:08:47 UTC