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Chromium
目标名称
Histone deacetylase 1
作用机理
Chromium can cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. (A35)
参考文献
A35 - Schnekenburger M, Talaska G, Puga A: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol. 2007 Oct;27(20):7089-101. Epub 2007 Aug 6. (17682057)
创建于
2009-04-14 21:08:39 UTC
更新于
2014-09-04 16:09:06 UTC