毒素T3DB ID

T3D0061

目标BioDB ID

BE0004994

目标名称

Sodium/potassium-transporting ATPase subunit beta-1

目标UniProt ID

P05026

作用机理

Like DDT, methoxychlor may also inhibit neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase and Ca2+-ATPase, which play vital roles in neuronal repolarization. This contributes to the reduced rate of depolarization and increases the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. (T10, A118)

参考文献

A118 - Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S: Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol. 2000 Oct;58(4):852-8. (10999957) T10 - Casarett LJ, Klaassen CD, and Watkins JB (2003). Casarett and Doull's essentials of toxicology. New York: McGraw-Hill/Medical Pub. Div.

创建于

2009-04-14 21:08:39 UTC

更新于

2014-09-04 16:07:31 UTC

目标详情