当前位置:药药网 / 数据中心 / 毒素靶向作用机制
Pilocarpine
目标名称
Muscarinic acetylcholine receptor M2
作用机理
Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.
参考文献
A365 - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. (11752352)
A9762 - Jakubik J, Bacakova L, El-Fakahany EE, Tucek S: Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. (9224827)
创建于
2009-07-22 22:37:15 UTC
更新于
2014-09-04 16:18:45 UTC