毒素T3DB ID

T3D2975

目标BioDB ID

BE0000406

目标名称

Carnitine O-palmitoyltransferase 1, liver isoform

目标UniProt ID

P50416

作用机理

Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fatty acids to carbohydrates through inhibition of CPT-1 and, to a lesser extent, CPT-2, resulting in increased glucose and lactate utilization.

参考文献

A308 - Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M: DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. (18048412) A8530 - Ceccarelli SM, Chomienne O, Gubler M, Arduini A: Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem. 2011 May 12;54(9):3109-52. doi: 10.1021/jm100809g. Epub 2011 Apr 19. (21504156)

创建于

2009-07-22 22:37:14 UTC

更新于

2014-09-04 16:22:36 UTC

目标详情