毒素T3DB ID

T3D0050

目标BioDB ID

BE0000132

目标名称

Androgen receptor

目标UniProt ID

P10275

作用机理

DDT is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (L85)

参考文献

A9667 - Maness SC, McDonnell DP, Gaido KW: Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol. 1998 Jul;151(1):135-42. (9705896) A9962 - van der Burg B, Winter R, Man HY, Vangenechten C, Berckmans P, Weimer M, Witters H, van der Linden S: Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds. Reprod Toxicol. 2010 Aug;30(1):18-24. doi: 10.1016/j.reprotox.2010.04.012. Epub 2010 May 10. (20438827) A10010 - Zhao HT, Zhu JB, Zhu YF, Wang Z, Ma X, Zhang T: [Establishment of reporter gene-based assays for the identification of (anti) androgenic effects of chemicals in CHO cells]. Wei Sheng Yan Jiu. 2005 May;34(3):281-4. (16111029) L85 - ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for DDT, DDE, and DDD. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp35.html)

创建于

2009-04-14 21:08:38 UTC

更新于

2014-09-04 16:05:37 UTC

目标详情