毒素T3DB ID

T3D2973

目标BioDB ID

BE0000530

目标名称

Serum albumin

目标UniProt ID

P02768

作用机理

Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

参考文献

A2100 - Fitos I, Simonyi M: Selective effect of clonazepam and (S)-uxepam on the binding of warfarin enantiomers to human serum albumin. J Chromatogr. 1988 Oct 21;450(2):217-20. (2906941) A2101 - Pacifici GM, Viani A, Rizzo G, Carrai M, Rane A: Plasma protein binding of clonazepam in hepatic and renal insufficiency and after hemodialysis. Ther Drug Monit. 1987 Dec;9(4):369-73. (3424402)

创建于

2009-07-22 22:37:13 UTC

更新于

2014-09-04 16:12:46 UTC

目标详情