毒素T3DB ID

T3D0048

目标BioDB ID

BE0000951

目标名称

Estrogen sulfotransferase

目标UniProt ID

P49888

作用机理

PCBs can cause endocrine disurption by binding to estrogen sulfotransferase, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. (A3, A66)

参考文献

A3 - Aoki Y: Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans as endocrine disrupters--what we have learned from Yusho disease. Environ Res. 2001 May;86(1):2-11. (11386736) A66 - Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ: Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology. 2000 May;141(5):1897-900. (10803601)

创建于

2009-04-14 21:08:38 UTC

更新于

2014-09-04 16:12:36 UTC

目标详情