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Aroclor 1221
目标名称
Aryl hydrocarbon receptor
作用机理
Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. (A4)
参考文献
A4 - Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W, et al.: PCBs: structure-function relationships and mechanism of action. Environ Health Perspect. 1985 May;60:47-56. (2992927)
创建于
2009-04-14 21:08:38 UTC
更新于
2014-09-04 16:10:37 UTC