毒素T3DB ID

T3D2972

目标BioDB ID

BE0000878

目标名称

Alpha-synuclein

目标UniProt ID

P37840

作用机理

Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.

参考文献

A2084 - Ishido M: Melatonin inhibits maneb-induced aggregation of alpha-synuclein in rat pheochromocytoma cells. J Pineal Res. 2007 Mar;42(2):125-30. (17286743) A2085 - Lin AM, Fang SF, Chao PL, Yang CH: Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. (17645694)

创建于

2009-07-22 22:37:13 UTC

更新于

2014-09-04 16:06:01 UTC

目标详情