毒素T3DB ID

T3D0028

目标BioDB ID

BE0003988

目标名称

Cytochrome c oxidase subunit 5A, mitochondrial

目标UniProt ID

P20674

作用机理

Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (L97)

参考文献

L97 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009. (http://en.wikipedia.org/wiki/Cyanide_poisoning)

创建于

2009-04-14 21:08:37 UTC

更新于

2014-09-04 16:11:42 UTC

目标详情