毒素T3DB ID

T3D3775

目标BioDB ID

BE0000045

目标名称

Muscarinic acetylcholine receptor M3

目标UniProt ID

P20309

作用机理

Slaframine is a parasympathomimetic compound and causes increased secretion by salivary glands, pancreas, and other exocrine and endocrine glands. This is due to its activity as a cholingergic agonist. Slaframine has a high affinity for muscarinic receptors, especially in the gastrointestinal tract, and it stimulates these to produce its parasympathomimetic effects. (A3091, A3092)

参考文献

A3091 - Chapa AM, Fernandez JM, Thompson DL Jr, Tempelman RJ, Berrio LF, Croom WJ Jr, Hagler WM Jr: Endocrine and metabolic response to muscarinic stimulation and inhibition in the ruminant: effects of slaframine. J Anim Sci. 1995 Dec;73(12):3673-80. (8655443) A3092 - Croom WJ Jr, Hagler WM Jr, Froetschel MA, Johnson AD: The involvement of slaframine and swainsonine in slobbers syndrome: a review. J Anim Sci. 1995 May;73(5):1499-508. (7665382)

创建于

2010-05-27 15:39:24 UTC

更新于

2014-09-04 16:18:46 UTC

目标详情