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Moniliformin
目标名称
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
作用机理
Moniliformin reversibly inhibits the enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase by competing for the binding site of pyruvate. This interferes with the tricarboxylic acid cycle by preventing the necessary incorporation of pyruvate and oxidation of the alpha-ketoglutarate intermediate. (A3077, A3078)
参考文献
A3077 - Jestoi M: Emerging fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin: a review. Crit Rev Food Sci Nutr. 2008 Jan;48(1):21-49. doi: 10.1080/10408390601062021. (18274964)
A3078 - Gathercole PS, Thiel PG, Hofmeyr JH: Inhibition of pyruvate dehydrogenase complex by moniliformin. Biochem J. 1986 Feb 1;233(3):719-23. (3707519)
创建于
2010-05-25 15:48:44 UTC
更新于
2014-09-04 16:13:15 UTC