Kojic acid
毒素T3DB ID
T3D3769
目标BioDB ID
BE0000252
目标名称
Tyrosinase
目标UniProt ID
P14679
作用机理
Kojic acid acts as a competitive and reversible inhibitor of animal and plant polyphenol oxidases (tyrosinases), which prevents melanosis by interfering with the uptake of O2. (A3073, A3074)
参考文献
A3073 - Burdock GA, Soni MG, Carabin IG: Evaluation of health aspects of kojic acid in food. Regul Toxicol Pharmacol. 2001 Feb;33(1):80-101. (11259181) A3074 - Noh JM, Kwak SY, Seo HS, Seo JH, Kim BG, Lee YS: Kojic acid-amino acid conjugates as tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5586-9. doi: 10.1016/j.bmcl.2009.08.041. Epub 2009 Aug 14. (19700313) A8195 - Liu T, Lin Y, Wen X, Jorissen RN, Gilson MK: BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res. 2007 Jan;35(Database issue):D198-201. Epub 2006 Dec 1. (17145705) A8630 - Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K: Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem. 2011 Apr;46(4):1374-81. doi: 10.1016/j.ejmech.2011.01.065. Epub 2011 Feb 3. (21334791) A8631 - Casanola-Martin GM, Khan MT, Marrero-Ponce Y, Ather A, Sultankhodzhaev MN, Torrens F: New tyrosinase inhibitors selected by atomic linear indices-based classification models. Bioorg Med Chem Lett. 2006 Jan 15;16(2):324-30. Epub 2005 Nov 3. (16275084) A8632 - Khan KM, Saify ZS, Khan MT, Butt N, Maharvi GM, Perveen S, Ambreen N, Choudhary MI, Atta-Ur-Rahman, Supuran CT: Tyrosinase inhibition: conformational analysis based studies on molecular dynamics calculations of bipiperidine based inhibitors. J Enzyme Inhib Med Chem. 2005 Aug;20(4):401-7. (16206837) A8633 - Kim H, Choi J, Cho JK, Kim SY, Lee YS: Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2843-6. (15125944) A8634 - Lee KH, Ab Aziz FH, Syahida A, Abas F, Shaari K, Israf DA, Lajis NH: Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur J Med Chem. 2009 Aug;44(8):3195-200. doi: 10.1016/j.ejmech.2009.03.020. Epub 2009 Mar 26. (19359068) A8635 - Su CR, Kuo PC, Wang ML, Liou MJ, Damu AG, Wu TS: Acetophenone derivatives from Acronychia pedunculata. J Nat Prod. 2003 Jul;66(7):990-3. (12880321) A8636 - Wu TS, Hsu MY, Kuo PC, Sreenivasulu B, Damu AG, Su CR, Li CY, Chang HC: Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity. J Nat Prod. 2003 Sep;66(9):1207-11. (14510598) A8637 - Likhitwitayawuid K, Sornsute A, Sritularak B, Ploypradith P: Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3. Epub 2006 Aug 17. (16919455) A8638 - Nihei Ki, Kubo I: Identification of oxidation product of arbutin in mushroom tyrosinase assay system. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2409-12. (12824045)
创建于
2010-05-21 17:37:16 UTC
更新于
2014-09-04 16:11:32 UTC
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