毒素T3DB ID

T3D0001

目标BioDB ID

BE0000143

目标名称

Tubulin beta chain

目标UniProt ID

P07437

作用机理

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (A17)

参考文献

A17 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. doi: 10.1016/j.jinorgbio.2007.10.021. Epub 2007 Nov 22. (18164070) A9735 - Zhang X, Yang F, Shim JY, Kirk KL, Anderson DE, Chen X: Identification of arsenic-binding proteins in human breast cancer cells. Cancer Lett. 2007 Sep 18;255(1):95-106. Epub 2007 May 17. (17499915)

创建于

2009-04-14 21:08:35 UTC

更新于

2014-09-04 16:05:00 UTC

目标详情