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Parathion
目标名称
Acetylcholinesterase
作用机理
The active metabolite of parathion, paraoxon, inactivates acetylcholinesterase by phosphorylating the active site of the enzyme, thus inhibiting its activity in the nervous system and at the motor end-plate. As a result, the neurotransmitter acetylcholine accumulates in the nerve synapse or neuromuscular junction, producing overstimulation of cholinergic end organs. (L634)
参考文献
L634 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Toxicological profile for methyl parathion U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp48.html)
创建于
2009-06-10 22:09:02 UTC
更新于
2014-09-04 16:14:04 UTC