毒素T3DB ID

T3D3767

目标BioDB ID

BE0000553

目标名称

Calcium-activated potassium channel subunit alpha-1

目标UniProt ID

Q12791

作用机理

The neurological effects of Lolitrem B are a result of its ability to inhibit large conductance calcium-activated potassium channels (BK channels). Lolitrem B binds to the alpha subunit of the BK channel, inhibiting channel potassium currents. This causes tremorgenic effects either by directly affecting channels in the muscle or by acting on channels in the central nervous system. (A3066, A3067)

参考文献

A3066 - Imlach WL, Finch SC, Dunlop J, Meredith AL, Aldrich RW, Dalziel JE: The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels. J Pharmacol Exp Ther. 2008 Dec;327(3):657-64. doi: 10.1124/jpet.108.143933. Epub 2008 Sep 18. (18801945) A3067 - Dalziel JE, Finch SC, Dunlop J: The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels. Toxicol Lett. 2005 Mar 15;155(3):421-6. (15649626)

创建于

2010-05-20 16:48:36 UTC

更新于

2014-09-04 16:18:18 UTC

目标详情