毒素T3DB ID

T3D0087

目标BioDB ID

BE0000337

目标名称

Transthyretin

目标UniProt ID

P02766

作用机理

2,4-Dinitrophenol has been suggested to bind serum proteins such as transthyretin. In fact it was proposed as a therapeutic agent for the prevention/inhibition of amyloid diseases through stabilization of the native fold of transthyretin. (A126,A127)

参考文献

A126 - Morais-de-Sa E, Neto-Silva RM, Pereira PJ, Saraiva MJ, Damas AM: The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin. Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):512-9. Epub 2006 Apr 19. (16627944) A127 - Xie Y, Zhang D, Ben-Amotz D: Protein-ligand binding detected using ultrafiltration Raman difference spectroscopy. Anal Biochem. 2008 Feb 1;373(1):154-60. Epub 2007 Nov 4. (18023404)

创建于

2009-05-21 17:35:27 UTC

更新于

2014-09-04 16:14:23 UTC

目标详情