毒素T3DB ID

T3D0056

目标BioDB ID

BE0000426

目标名称

Acetylcholinesterase

目标UniProt ID

P22303

作用机理

Diazoxon the main toxic intermediate of diazinon, inhibits acetylcholinesterase in the central and peripheral nervous system. This results in the accumulation of acetylcholine, causing excessive stimulation of cholinergic fibers in the postganglionic parasympathetic nerve endings, neuromuscular junctions of the skeletal muscles, and cells of the central nervous system that results in hyperpolarization and receptor desensitization. This produces muscarinic, nicotinic, and CNS effects. (L162)

参考文献

L162 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for diazinon. U.S. Public Health Service in collaboration with U.S. (http://www.atsdr.cdc.gov/toxprofiles/tp86.html)

创建于

2009-05-19 16:29:54 UTC

更新于

2014-09-04 16:14:03 UTC

目标详情