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1,2-Dichloroethane
目标名称
Protein disulfide-isomerase
作用机理
S-(2-chloroethyl)glutathione, one of the glutathione conjugates of 1,2-dichloroethane, is known to irreversibly inhibit protein disulfide-isomerase via alkylation. (A132)
参考文献
A132 - Kaetzel RS, Stapels MD, Barofsky DF, Reed DJ: Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts. Arch Biochem Biophys. 2004 Mar 1;423(1):136-47. (14871477)
创建于
2009-05-19 05:21:40 UTC
更新于
2014-09-04 16:17:38 UTC