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Nickel
目标名称
Putative histone H2B type 2-D
作用机理
Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. (L41)
参考文献
L41 - ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). (http://www.atsdr.cdc.gov/toxprofiles/tp15.html)
创建于
2009-05-14 21:48:28 UTC
更新于
2014-09-04 16:17:22 UTC