药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
multimodal antidepressant drugs, 321 321
primary site of BATs modeling, 324–326 326
vortioxetine, 322–323 323
receptor characterization, 330 330
MS, see Multiple sclerosis 0
Multidrug-resistant (MDR), 405 405
Multiple sclerosis (MS), 153, 342 342
Muscarinic ACh receptors (mAChRs), 280–285 285
allosteric and bitopic ligands, 282–283 283
ligand binding to and modulation, 283–285 285
orthosteric mAChR agonists, 281–282 282
nAChRs, see Nicotine acetylcholine receptors 0
NAMs, see Negative allosteric modulators 0
Narrow-spectrum antibiotics, 405 405
Native chemical ligation (NCL), 91–92 92
antiparasitic milbemycin analogs, 105–106 106
biosynthetic classes, 101–103 103
biosynthetic modifications 0
acetate-specific AT, 114–115 115
macbecin and nonquinone analogs, 112–113 113
mutasynthesis, 113–114 114
polyketide pathway, 113–115 115
cytotoxic antibiotics, 104–105 105
“Golden Age” of antibiotic discovery, 104–105 105
historical perspective, 103–104 104