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药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
multimodal antidepressant drugs, 321
321
primary site of BATs modeling, 324–326
324 326
receptor characterization, 330
330
MS, see Multiple sclerosis
Multidrug-resistant (MDR), 405
405
Multiple sclerosis (MS), 153, 342
153 342
Muscarine, 6–7, 281
6 7 281
Muscarinic ACh receptors (mAChRs), 280–285
280 285
allosteric and bitopic ligands, 282–283
282 283
ligand binding to and modulation, 283–285
283 285
orthosteric mAChR agonists, 281–282
281 282
nAChRs, see Nicotine acetylcholine receptors
NAMs, see Negative allosteric modulators
Narrow-spectrum antibiotics, 405
405
Native chemical ligation (NCL), 91–92
91 92
antiparasitic milbemycin analogs, 105–106
105 106
biosynthetic classes, 101–103
101 103
biosynthetic modifications
acetate-specific AT, 114–115
114 115
macbecin and nonquinone analogs, 112–113
112 113
mutasynthesis, 113–114
113 114
polyketide pathway, 113–115
113 115
cytotoxic antibiotics, 104–105
104 105
“Golden Age” of antibiotic discovery, 104–105
104 105
historical perspective, 103–104
103 104