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药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
physical properties, 124
124
short-lived and long-lived isotopes, 124
124
selectivity and Bmax, 123
123
tracer principle, 123
123
butyrylcholinesterase catalyzed hydrolysis,169–170
169 170
clopidogrel and prasugrel, 167–168
167 168
HepDirect®-prodrugs, 168–169
168 169
improved formulation and administration,161–162
161 162
improved passive permeability, 163–165
163 165
improved transporter-mediated permeability,165–166 165–166
prolonged duration, 170
170
site-specific bioactivation, 166
166
tumor-selective activation pathway, 167
167
chemical derivatives, 155–156
155 156
discovery and development
regulatory aspects, 172–173
172 173
safety evaluation, 172
172
functional groups, 158–159
158 159
Protein biosynthesis, 421–425
421 425
30S ribosomal subunit inhibitors, 421
421