药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
classical unselective opiates, 333 333
dimeric/bivalent opioid receptor ligands, 335–336 336
medicinal chemistry approaches, 333 333
peptidomimetic ligands, 337 337
structural classes, 334–335 335
subtypes and effector mechanism, 330 330
therapeutic applications, 337–338 338
golden triangle, 64–65 65
partition coefficient P or D, 62–63 63
physicochemical properties, 63 63
physicochemical/theoretical descriptors, 62 62
small-molecule, analysis of, 65, 67 67
Organic calcium blockers, 225 225
PAMs, see Positive allosteric modulators 0
Pandrug-resistant (PDR), 405 405
PASylation technology, 141 141
Patch–clamp method, 215–216 216
PEG, see Polyethylene glycol 0
68Ga, 64Cu, and 89Zr, 125–126 126