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药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
classical unselective opiates, 333
333
dimeric/bivalent opioid receptor ligands, 335–336
335 336
medicinal chemistry approaches, 333
333
peptidomimetic ligands, 337
337
structural classes, 334–335
334 335
subtypes and effector mechanism, 330
330
therapeutic applications, 337–338
337 338
CNS MPO-score, 65–67
65 67
golden triangle, 64–65
64 65
partition coefficient P or D, 62–63
62 63
physicochemical properties, 63
63
physicochemical/theoretical descriptors, 62
62
small-molecule, analysis of, 65, 67
65 67
Organic calcium blockers, 225
225
PAMs, see Positive allosteric modulators
Pandrug-resistant (PDR), 405
405
PASylation technology, 141
141
Patch–clamp method, 215–216
215 216
PEG, see Polyethylene glycol
68Ga, 64Cu, and 89Zr, 125–126
125 126